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Article

p21WAF1/CIP1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations.

The Journal of pathology - 1 Feb 1999

Viale G, Pellegrini C, Mazzarol G, Maisonneuve P, Silverman M L, Bosari S

Abstract excerpt

Defects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumour progression. p21WAF1/CIP1 is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21WAF1/CIP1 expression has been investigated immunohistochemically in a series of 191 patients with colorectal cancer of known p53...

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Identifiers

PMID: 10398083
DOI: 10.1002/(SICI)1096-9896(199902)187:3<302::AID-PATH243>3.0.CO;2-U

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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