PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells.

doi:10.1038/sj.onc.1201221

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells.

Oncogene - 31 Jul 1997

Alimandi M, Heidaran M A, Gutkind J S, Zhang J, Ellmore N, Valius M, Kazlauskas A, Pierce J H, Li W

Abstract excerpt

To investigate the molecular mechanisms mediating hematopoietic cell differentiation and mitogenesis by activation of the platelet-derived growth factor beta receptor (PDGF-betaR), the wild type PDGF-betaR (PDGF-betaRWT) and tyrosine to phenylalanine mutants of the PDGF-betaR, including F751, F96...

Topics

Binding Sites
Cell Differentiation
DNA
Enzyme Activation
Enzyme Inhibitors
Humans
Indoles
Isoenzymes
Maleimides
Monocytes
Mutation
Phenylalanine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phospholipase C gamma

Phosphorylation

Platelet-Derived Growth Factor

Receptor, Platelet-Derived Growth Factor beta

Receptors, Platelet-Derived Growth Factor

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 9247312
DOI: 10.1038/sj.onc.1201221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9247312-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells.PMID 9247312Read ↗

PDGF receptor signaling networks in normal and cancer cellsSemantic proximity Read ↗

Roles of PDGF/PDGFR signaling in various organsSemantic proximity Read ↗

Role of platelet-derived growth factors in physiology and medicine.Semantic proximity Read ↗

Platelet-derived Growth Factor Signaling and Human CancerSemantic proximity Read ↗

Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes.Semantic proximity Read ↗

Insight into the physiological functions of PDGF through genetic studies in mice.Semantic proximity Read ↗

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta.Semantic proximity Read ↗

Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice.Semantic proximity Read ↗

The TEL/PDGFbetaR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways.Semantic proximity Read ↗

The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.Semantic proximity Read ↗

Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.Semantic proximity Read ↗

JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-gamma and the phosphatidylinositol 3-kinase signaling pathways of the receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.