Article
The TEL/PDGFbetaR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways.
Blood - 1 Dec 2001
Sternberg D W, Tomasson M H, Carroll M, Curley D P, Barker G, Caprio M, Wilbanks A, Kazlauskas A, Gilliland D G
Abstract excerpt
The TEL/PDGFbetaR gene, which encodes a fusion protein containing the ETS-family member TEL fused to the protein-tyrosine kinase domain of the platelet-derived growth factor receptor-beta (PDGFbetaR), confers interleukin 3 (IL-3)-independent growth on Ba/F3 hematopoietic cells. TEL/PDGFbetaR mutants have been generated that contain tyrosine-to-phenylalanine (Tyr-->Phe) substitutions at phosphorylation sites...
Topics
- Animals
- Binding Sites
- Cell Line
- DNA-Binding Proteins
- Leukemia, Myelomonocytic, Chronic
- Mice
- Milk Proteins
- Mutation
- Oncogene Proteins, Fusion
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Phosphotyrosine
- Protein-Tyrosine Kinases