Article
Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.
The Journal of cell biology - 1 Oct 1994
Yu J C, Gutkind J S, Mahadevan D, Li W, Meyers K A, Pierce J H, Heidaran M A
Abstract excerpt
The tyrosine phosphorylation sites in the human alpha PDGF receptor (alpha PDGFR) required for association with PI-3 kinase have been identified as tyrosines 731 and 742. Mutation of either tyrosine substantially reduced PDGF-induced PI-3 kinase activity but did not impair the receptor-mediated m...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Chemotaxis
- Enzyme Activation
- Enzyme Induction
- Mice
- Mitogen-Activated Protein Kinase 1
- Molecular Sequence Data
- Mutation
- Phosphatidylinositol 3-Kinases