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Article

Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.

The Journal of cell biology - 1 Oct 1994

Yu J C, Gutkind J S, Mahadevan D, Li W, Meyers K A, Pierce J H, Heidaran M A

Abstract excerpt

The tyrosine phosphorylation sites in the human alpha PDGF receptor (alpha PDGFR) required for association with PI-3 kinase have been identified as tyrosines 731 and 742. Mutation of either tyrosine substantially reduced PDGF-induced PI-3 kinase activity but did not impair the receptor-mediated mitogenic response. We sought to determine whether PDGF-induced PI-3 kinase activity could be further ablated so as to...

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Identifiers

PMID: 7929590
DOI: 10.1083/jcb.127.2.479
PMCID: PMC2120211

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