Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta.

Nature - 3 Feb 1994

Kundra V, Escobedo J A, Kazlauskas A, Kim H K, Rhee S G, Williams L T, Zetter B R

Abstract excerpt

Chemotaxis is an important component of wound healing, development, immunity and metastasis, yet the signalling pathways that mediate chemotaxis are poorly understood. Platelet-derived growth factor (PDGF) acts both as a mitogen and a chemoattractant. Upon stimulation, the tyrosine kinase PDGF re...

Topics

3T3 Cells
Animals
Becaplermin
CHO Cells
Cattle
Cell Line
Chemotaxis
Cricetinae
GTPase-Activating Proteins
Humans
Mice
Mutation
Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphotransferases (Alcohol Group Acceptor)

Platelet-Derived Growth Factor

Proteins

Proto-Oncogene Proteins c-sis

Receptor Protein-Tyrosine Kinases

Source

Identifiers

PMID: 8107807
DOI: 10.1038/367474a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8107807-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta.PMID 8107807Read ↗

The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.Semantic proximity Read ↗

Roles of PDGF/PDGFR signaling in various organsSemantic proximity Read ↗

Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes.Semantic proximity Read ↗

PDGF receptor signaling networks in normal and cancer cellsSemantic proximity Read ↗

Platelet-derived Growth Factor Signaling and Human CancerSemantic proximity Read ↗

Role of platelet-derived growth factors in physiology and medicine.Semantic proximity Read ↗

A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.Semantic proximity Read ↗

Platelet-derived growth factor (PDGF) receptor-alpha activates c-Jun NH2-terminal kinase-1 and antagonizes PDGF receptor-beta -induced phenotypic transformation.Semantic proximity Read ↗

Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration.Semantic proximity Read ↗

JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-gamma and the phosphatidylinositol 3-kinase signaling pathways of the receptor.Semantic proximity Read ↗

Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.Semantic proximity Read ↗

Directional Cell Migration and Chemotaxis in Wound Healing Response to PDGF-AA are Coordinated by the Primary Cilium in FibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.