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Article

Costars, a Dictyostelium protein similar to the C-terminal domain of STARS, regulates the actin cytoskeleton and motility.

Journal of cell science - 1 Nov 2010

Pang Te-Ling, Chen Fung-Chi, Weng Yi-Lan, Liao Hsien-Ching, Yi Yung-Hsiang, Ho Chia-Lin, Lin Chi-Hung, Chen Mei-Yu

Abstract excerpt

Through analysis of a chemotaxis mutant obtained from a genetic screen in Dictyostelium discoideum, we have identified a new gene involved in regulating cell migration and have named it costars (cosA). The 82 amino acid Costars protein sequence appears highly conserved among diverse species, and significantly resembles the C-terminal region of the striated muscle activator of Rho signaling (STARS), a mammalian...

Topics

Actins
Amino Acid Sequence
Cell Movement
Conserved Sequence
Cytoskeleton
Dictyostelium
Evolution, Molecular
Genetic Testing
Humans
Microfilament Proteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Structure, Tertiary

Protozoan Proteins

Sequence Homology, Amino Acid

Transcription Factors

Source

Identifiers

PMID: 20940261
DOI: 10.1242/jcs.064709

Provenance

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Costars, a Dictyostelium protein similar to the C-terminal domain of STARS, regulates the actin cytoskeleton and motility.PMID 20940261Read ↗

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