Article
Abnormalities of sensory and memory functions in mice lacking Bsg gene.
Biochemical and biophysical research communications - 30 Jul 1997
Naruhashi K, Kadomatsu K, Igakura T, Fan Q W, Kuno N, Muramatsu H, Miyauchi T, Hasegawa T, Itoh A, Muramatsu T, Nabeshima T
Abstract excerpt
Basigin is a highly glycosylated transmembrane protein belonging to the immunoglobulin superfamily. We used mutant mice lacking the basigin gene (Bsg) to investigate its involvement in learning and memory. Mutations were generated by the gene targeting method. Various kinds of learning and memory tasks were performed in mutant, hetero and wild type mice. The mutant mice showed worse performance than the wild and...
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