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Article

Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Oct 2010

Tamura Takuya, Horiuchi Daisuke, Chen Yi-Chung, Sone Masaki, Miyashita Tomoyuki, Saitoe Minoru, Yoshimura Natsue, Chiang Ann-Shyn, Okazawa Hitoshi

Abstract excerpt

Polyglutamine tract-binding protein-1 (PQBP1) is involved in the transcription-splicing coupling, and its mutations cause a group of human mental retardation syndromes. We generated a fly model in which the Drosophila homolog of PQBP1 (dPQBP1) is repressed by insertion of piggyBac. In classical odor conditioning, learning acquisition was significantly impaired in homozygous piggyBac-inserted flies, whereas the...

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Identifiers

PMID: 20962230
DOI: 10.1523/JNEUROSCI.1319-10.2010
PMCID: PMC6634781

Genes

PQBP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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