Article
A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis.
Developmental biology - 15 Feb 1998
Igakura T, Kadomatsu K, Kaname T, Muramatsu H, Fan Q W, Miyauchi T, Toyama Y, Kuno N, Yuasa S, Takahashi M, Senda T, Taguchi O, Yamamura K, Arimura K, Muramatsu T
Abstract excerpt
Basigin is a highly glycosylated transmembrane protein with two immunoglobulin-like domains. We generated mutant mice lacking the basigin gene (Bsg) by gene targeting. Bsg (-/-) embryos developed normally during preimplantation stages. However, the majority of Bsg (-/-) embryos died around the ti...
Topics
- Animals
- Antigens, CD
- Antigens, Neoplasm
- Antigens, Surface
- Avian Proteins
- Basigin
- Blood Proteins
- Embryo Implantation
- Female
- Male
- Membrane Glycoproteins
- Mice
- Mice, Knockout
- Mice, Mutant Strains