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Article

Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging.

Behavioural brain research - 2 Mar 2009

Tajima Orie, Egashira Nobuaki, Ohmi Yuhsuke, Fukue Yoshihiko, Mishima Kenichi, Iwasaki Katsunori, Fujiwara Michihiro, Inokuchi Jinichi, Sugiura Yasuo, Furukawa Keiko, Furukawa Koichi

Abstract excerpt

Sialic acid-containing glycosphingolipids (gangliosides) have been believed to play a role in the regulation and protection of nervous tissues. To clarify their function in the nervous system in vivo, double knockout (DKO) mice of GM2/GD2 synthase and GD3 synthase genes were generated and abnormal behaviors were analyzed. Mutant mice exhibited reduced weight and a round shape of the whole brain that progressively...

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Identifiers

PMID: 19013484
DOI: 10.1016/j.bbr.2008.10.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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