Article
Role of H-ras gene in chronic liver damage in mice. By using transgenic mice carrying a human C-H-ras proto-oncogene without mutations.
Biochemistry and molecular biology international - 1 Jun 1997
Tsunematsu S, Saito H, Sato R, Morizane T, Ishii H
Abstract excerpt
Hepatic tumors including hepatocellular carcinoma were generated by carbon tetrachloride in transgenic mice carrying a human c-H-ras gene (rasH2 mice). RasH2 mice express 2 to 3 times more ras protein (ras p21) in the liver than do non-Tg mice. When carbon tetrachloride was administered, the rasH...
Topics
- Animals
- Carbon Tetrachloride
- Carcinoma, Hepatocellular
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- Liver
- Liver Neoplasms, Experimental
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Proto-Oncogene Mas
- ras Proteins