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Article

Stimulation of the collagen α1(I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis

1 Feb 1993

Abstract excerpt

Cirrhosis is characterized by a marked increase in the deposition of type I collagen and in the expression of the type I collagen genes alpha 1(I) and alpha 2(I). Although alpha 1(I) gene regulation has been extensively studied in cultured cells, these results may not be applicable to hepatic fibrogenesis in vivo. Therefore the regulation of the alpha 1(I) endogenous gene and an alpha 1(I) transgene was studied...

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PMID: 8428727
DOI: 10.1002/hep.1840170220

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Source receipt: pubmed, retrieved 7 Sept 2026.

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