Article
Rare activation of the human c-Ha-ras transgene of mice in hemangioendothelial sarcomas and liver tumors induced by Glu-P-1.
Japanese journal of cancer research : Gann - 1 Jun 1996
Inoue R, Ushijima T, Katami M, Kushida H, Wakabayashi K, Sato H, Asamoto M, Katsuki M, Sugimura T, Nagao M
Abstract excerpt
A transgenic mouse (Tg), having the human c-Ha-ras proto-oncogene, has been demonstrated to develop hemangioendothelial sarcomas (HESs) which are associated with the transgene mutation, but not to develop liver tumors. In this study, we examined the effects of 2-amino-6-methyldipyrido [1,2-a:3',2'-d] imidazole (Glu-P-1), a food-borne carcinogen, which has been demonstrated to induce HESs and liver tumors in CDF1...
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