Article
Role of activated c-H-ras oncogene in the induction and progression of immortal liver epithelial cell lines derived from normal C3H mice.
International journal of cancer - 2 Jan 1991
Lee G H, Sakai R, Nagao M, Kitagawa T
Abstract excerpt
The nature of 15 immortal mouse liver epithelial cell (MLEC) lines established from normal C3H mice was investigated specifically in terms of ras oncogene activation. Neither transforming activity nor point mutation within codon 61 of c-H-ras could be demonstrated in any of the cell lines by DNA...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Cell Line
- Cell Transformation, Neoplastic
- Codon
- Gene Expression
- Genes, ras
- Liver
- Liver Neoplasms, Experimental
- Mice
- Mice, Inbred C3H
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Oncogene Protein p21(ras)
- Polymerase Chain Reaction