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Article

Mutation and overexpression of the transgene in ethylnitrosourea-induced tumors in mice carrying a human prototype c-Ha-ras gene.

Toxicologic pathology - 1 Jan 2000

Toyosawa Kaoru, Tanaka Kohji, Imai Toshio, Yasuhara Kazuo, Koujitani Takatoshi, Hirose Masao, Mitsumori Kunitoshi

Abstract excerpt

To investigate mechanisms underlying accelerated carcinogenesis in mice carrying a human prototype c-Ha-ras gene (rasH2 mouse), mutations and the expression profile of the transgene were evaluated in 14 tumors induced by a single injection of ethylnitrosourea (ENU), with or without additional beta-estradiol 3-benzoate (EB) treatment. Although no codon 12 mutations were detected, changes in codon 61 were evident...

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Source

Identifiers

PMID: 14692617
DOI: 10.1080/01926230390224683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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