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Article

p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases.

Molecular and cellular biology - 1 Aug 1997

Saha P, Eichbaum Q, Silberman E D, Mayer B J, Dutta A

Abstract excerpt

Cdc25A, a phosphatase essential for G1-S transition, associates with, dephosphorylates, and activates the cell cycle kinase cyclin E-cdk2. p21CIP1 and p27 are cyclin-dependent kinase (cdk) inhibitors induced by growth-suppressive signals such as p53 and transforming growth factor beta (TGF-beta). We have identified a cyclin binding motif near the N terminus of Cdc25A that is similar to the cyclin binding Cy (or...

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Identifiers

PMID: 9234691
DOI: 10.1128/MCB.17.8.4338
PMCID: PMC232287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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