Article
p21 contains independent binding sites for cyclin and cdk2: both sites are required to inhibit cdk2 kinase activity.
Oncogene - 16 May 1996
Fotedar R, Fitzgerald P, Rousselle T, Cannella D, Dorée M, Messier H, Fotedar A
Abstract excerpt
Cyclin dependent kinases regulate the progression of eukaryotic cells through the cell cycle. p21Cip1/Waf1/Sdi1 is an inhibitor of cdk-cyclin kinase activity, and has been shown to form complexes with cdk-cyclins and with PCNA, an accessory protein of DNA polymerase delta. The kinase inhibitory d...
Topics
- Amino Acid Sequence
- Animals
- Baculoviridae
- Binding Sites
- Burkitt Lymphoma
- CDC2-CDC28 Kinases
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases
- Cyclins
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Mapping
- Protein Serine-Threonine Kinases
- Spodoptera
- Tumor Cells, Cultured