Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation.

doi:10.18632/oncotarget.10330

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Article

Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation.

Oncotarget - 2 Aug 2016

Kreis Nina-Naomi, Friemel Alexandra, Zimmer Brigitte, Roth Susanne, Rieger Michael A, Rolle Udo, Louwen Frank, Yuan Juping

Abstract excerpt

The multifunctional protein p21Cip1/CDKN1A (p21) is an important and universal Cdk-interacting protein. Recently, we have reported that p21 is involved in the regulation of the mitotic kinase Cdk1/cyclin B1 and critical for successful mitosis and cytokinesis. In the present work we show that S130 of p21 is phosphorylated by Cdk1/cyclin B1 during mitosis, which reduces p21's stability and binding affinity to...

Topics

CDC2 Protein Kinase
Carcinogenesis
Chromosomal Instability
Cyclin-Dependent Kinase Inhibitor p21
HCT116 Cells
HeLa Cells
Humans
MCF-7 Cells
Mitosis
Mutation
Neoplasms
Phosphorylation
Recombinant Proteins
Transcriptional Activation

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Identifiers

PMID: 27384476
DOI: 10.18632/oncotarget.10330
PMCID: PMC5226578

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