Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Some properties of the hazard function of the two-mutation clonal expansion model.

Risk analysis : an official publication of the Society for Risk Analysis - 1 Jun 1997

Heidenreich W F, Luebeck E G, Moolgavkar S H

Abstract excerpt

We discuss the hazard function of the two-mutation clonal expansion model with time-dependent parameters, with particular emphasis on identifiability of the parameters. We explicitly construct identifiable parameter combinations, and illustrate the properties of the hazard function under perturba...

Topics

Animals
Cocarcinogenesis
Humans
Mathematics
Models, Biological
Mutation
Proportional Hazards Models
Risk

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9232020
DOI: 10.1111/j.1539-6924.1997.tb00878.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9232020-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Some properties of the hazard function of the two-mutation clonal expansion model.PMID 9232020Read ↗

On the parameters of the clonal expansion model.Semantic proximity Read ↗

An improved approximation to the exact solution of the two-stage clonal growth model of cancer.Semantic proximity Read ↗

Limits of applicability for the deterministic approximation of the two-step clonal expansion model.Semantic proximity Read ↗

An exact representation for the generating function for the Moolgavkar-Venzon-Knudson two-stage model of carcinogenesis with stochastic stem cell growth.Semantic proximity Read ↗

Accurate prediction of the age incidence of chronic myeloid leukemia with an improved two-mutation mathematical model.Semantic proximity Read ↗

Parameter estimation for multistage clonal expansion models from cancer incidence data: A practical identifiability analysis.Semantic proximity Read ↗

The evolution of two mutations during clonal expansion.Semantic proximity Read ↗

Preventing clonal evolutionary processes in cancer: Insights from mathematical models.Semantic proximity Read ↗

Computational tools for assessing gene therapy under branching process models of mutation.Semantic proximity Read ↗

Exact solutions of the clonal expansion model and their application to the incidence of solid tumors of atomic bomb survivors.Semantic proximity Read ↗

A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues.Semantic proximity Read ↗

The roles of T cell competition and stochastic extinction events in chimeric antigen receptor T cell therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.