The evolution of two mutations during clonal expansion.

doi:10.1534/genetics.107.078915

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Article

The evolution of two mutations during clonal expansion.

Genetics - 1 Dec 2007

Haeno Hiroshi, Iwasa Yoh, Michor Franziska

Abstract excerpt

Knudson's two-hit hypothesis proposes that two genetic changes in the RB1 gene are the rate-limiting steps of retinoblastoma. In the inherited form of this childhood eye cancer, only one mutation emerges during somatic cell divisions while in sporadic cases, both alleles of RB1 are inactivated in the growing retina. Sporadic retinoblastoma serves as an example of a situation in which two mutations are accumulated...

Topics

Cell Proliferation
Clone Cells
Disease
Drug Resistance
Evolution, Molecular
Humans
Kinetics
Models, Genetic
Mutation
Neoplasm Invasiveness

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Identifiers

PMID: 18073428
DOI: 10.1534/genetics.107.078915
PMCID: PMC2219486

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