An exact representation for the generating function for the Moolgavkar-Venzon-Knudson two-stage model of carcinogenesis with stochastic stem cell growth.

doi:10.1016/0025-5564(95)00046-1

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Article

An exact representation for the generating function for the Moolgavkar-Venzon-Knudson two-stage model of carcinogenesis with stochastic stem cell growth.

Mathematical biosciences - 15 Jan 1996

Denes J, Krewski D

Abstract excerpt

The two-stage clonal expansion model of carcinogenesis provides a convenient biologically based framework for the quantitative description of carcinogenesis data. Under this stochastic model, a cancer cell arises following the occurrence of two critical mutations in a normal stem cell. Both norma...

Topics

Animals
Cell Division
Cocarcinogenesis
Humans
Mathematics
Models, Biological
Mutation
Neoplastic Stem Cells
Probability
Proportional Hazards Models
Stochastic Processes

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