An exact representation for the generating function for the Moolgavkar-Venzon-Knudson two-stage model of carcinogenesis with stochastic stem cell growth.

Abstract excerpt

The two-stage clonal expansion model of carcinogenesis provides a convenient biologically based framework for the quantitative description of carcinogenesis data. Under this stochastic model, a cancer cell arises following the occurrence of two critical mutations in a normal stem cell. Both normal cells and initiated cells that have sustained the first mutation undergo birth-and-death processes responsible for...

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