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Article

Parameter estimation for multistage clonal expansion models from cancer incidence data: A practical identifiability analysis.

PLoS computational biology - 1 Mar 2017

Brouwer Andrew F, Meza Rafael, Eisenberg Marisa C

Abstract excerpt

Many cancers are understood to be the product of multiple somatic mutations or other rate-limiting events. Multistage clonal expansion (MSCE) models are a class of continuous-time Markov chain models that capture the multi-hit initiation-promotion-malignant-conversion hypothesis of carcinogenesis. These models have been used broadly to investigate the epidemiology of many cancers, assess the impact of carcinogen...

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Identifiers

PMID: 28288156
DOI: 10.1371/journal.pcbi.1005431
PMCID: PMC5367820

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Source receipt: pubmed, retrieved 7 Sept 2026.

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