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Article

Limits of applicability for the deterministic approximation of the two-step clonal expansion model.

Risk analysis : an official publication of the Society for Risk Analysis - 1 Feb 2001

Heidenreich W F, Hoogenveen R

Abstract excerpt

Motivated by a hypothesis published recently, the limits of applicability of the deterministic approximation of the two-step clonal expansion model are investigated. The approximate hazard increases unlimited, while the exact hazard is approaching a constant value. The approximate solution becomes inapplicable for hazards in the order of that constant rate. When the initiation rate is much larger than the cell...

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PMID: 11332539
DOI: 10.1111/0272-4332.211093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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