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Article

The roles of T cell competition and stochastic extinction events in chimeric antigen receptor T cell therapy

24 Mar 2021

Abstract excerpt

expansion of engineered CAR T cells, after lymphodepletion (LD) by chemotherapy. The quantitative laws underlying this expansion and subsequent tumour eradication remain unknown. We develop a mathematical model of T cell-tumour cell interactions and demonstrate that expansion can be explained by immune reconstitution dynamics after LD and competition among T cells. CAR T cells rapidly grow and engage tumour cells...

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PMID: 33757357
DOI: 10.1098/rspb.2021.0229

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