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Article

Accurate prediction of the age incidence of chronic myeloid leukemia with an improved two-mutation mathematical model.

Integrative biology : quantitative biosciences from nano to macro - 5 Dec 2016

Lecca Paola, Sorio Claudio

Abstract excerpt

Chronic myeloid leukemia (CML) is a malignant clonal disorder whose hallmark is a reciprocal translocation between chromosomes 9 and 22 occurring in 95% of affected patients. This translocation causes the expression of a deregulated BCR/ABL fusion oncogene and, interestingly, is detectable in healthy individuals. Based on this information we assumed that the sole presence of the BCR/ABL transcript represents a...

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PMID: 27801472
DOI: 10.1039/c6ib00127k

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BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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