Computational tools for assessing gene therapy under branching process models of mutation.

Abstract excerpt

Multitype branching processes are ideal for studying the population dynamics of stem cell populations undergoing mutation accumulation over the years following transplant. In such stochastic models, several quantities are of clinical interest as insertional mutagenesis carries the potential threat of leukemogenesis following gene therapy with autologous stem cell transplantation. In this paper, we develop a...

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