Accumulation of wild-type p53 in astrocytomas is associated with increased p21 expression.

doi:10.1007/s004010050667

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Article

Accumulation of wild-type p53 in astrocytomas is associated with increased p21 expression.

Acta neuropathologica - 1 Jul 1997

Ono Y, Tamiya T, Ichikawa T, Matsumoto K, Furuta T, Ohmoto T, Akiyama K, Seki S, Ueki K, Louis D N

Abstract excerpt

Approximately one quarter of human astrocytomas show immunohistochemical positivity for p53 protein but lack p53 gene mutations, which could reflect either an accumulation of wild-type p53 protein or an inadequate sensitivity of mutation detection. Since wild-type p53 up-regulates p21 expression,...

Topics

Adolescent
Adult
Aged
Astrocytoma
Brain Neoplasms
Cell Division
Child
Child, Preschool
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Female
Genes, p53
Humans
Immunohistochemistry
Infant
Male
Middle Aged
Mutation

Source

Open in PubMed

Identifiers

PMID: 9224526
DOI: 10.1007/s004010050667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9224526-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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