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Article

Accumulation of wild type p53 protein in human astrocytomas.

Cancer research - 1 Aug 1993

Rubio M P, von Deimling A, Yandell D W, Wiestler O D, Gusella J F, Louis D N

Abstract excerpt

We have previously described 10 astrocytomas with accumulation of p53 protein but no mutations in p53 exons 5-8, and we have suggested that they might represent overexpression of wild type protein or mutations in less conserved regions of the gene. To investigate these possibilities further, we s...

Topics

Astrocytoma
Base Sequence
Gene Amplification
Genes, p53
Humans
Molecular Sequence Data
Mutation
Neoplasm Proteins
Nuclear Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2
Tumor Suppressor Protein p53

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Identifiers

PMID: 8339248

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MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8339248-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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