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Article

Accumulation of wild type p53 protein in human astrocytomas.

Cancer research - 1 Aug 1993

Rubio M P, von Deimling A, Yandell D W, Wiestler O D, Gusella J F, Louis D N

Abstract excerpt

We have previously described 10 astrocytomas with accumulation of p53 protein but no mutations in p53 exons 5-8, and we have suggested that they might represent overexpression of wild type protein or mutations in less conserved regions of the gene. To investigate these possibilities further, we studied the tumors with immunohistochemistry for wild type and mutant p53 protein and showed that all cases stained with...

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PMID: 8339248

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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