Article
Differential p53, p21, mdm2 and Rb regulation in glioma cell lines that overexpress wild-type p53.
International journal of oncology - 1 Aug 1998
Pykett M J, Azzam E, Dahlberg W, Little J B
Abstract excerpt
Gliomas are part of a subset of tumors in which overexpression of p53 protein in the absence of p53 gene mutation has been described. We have utilized a series of glioma cell lines to study the effects of ionizing radiation on the regulation of p53, p21, mdm2 and Rb proteins. The induction of p53...
Topics
- Astrocytes
- Blotting, Western
- Fibroblasts
- Gene Expression Regulation, Neoplastic
- Glioma
- Humans
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Oncogene Protein p21(ras)
- Phosphorylation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2
- Retinoblastoma Protein
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53