Article
Regulation and function of the multidrug resistance genes in liver.
Progress in liver diseases - 1 Jan 1995
Silverman J A, Thorgeirsson S S
Abstract excerpt
The P-glycoproteins are integral membrane proteins that function as ATP-dependent transporters. The multidrug resistance genes which encode P-gp comprise a small gene family, with 2 members in humans and 3 in rodents. The P-gp encoded by the mdr1 gene functions as a drug efflux pump to remove dru...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Adenosine Triphosphate
- Animals
- Cloning, Molecular
- Drug Resistance, Multiple
- Gene Expression
- Genome
- Humans
- Liver
- Mice
- Molecular Structure
- Phenotype
- Phospholipids