Article
Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease.
Cell - 5 Nov 1993
Smit J J, Schinkel A H, Oude Elferink R P, Groen A K, Wagenaar E, van Deemter L, Mol C A, Ottenhoff R, van der Lugt N M, van Roon M A
Abstract excerpt
Two types of P-glycoprotein have been found in mammals: the drug-transporting P-glycoproteins and a second type, unable to transport hydrophobic anticancer drugs. The latter is encoded by the human MDR3 (also called MDR2) and the mouse mdr2 genes, and its tissue distribution (bile canalicular membrane of hepatocytes, B cells, heart, and muscle) suggests a specialized metabolic function. We have generated mice...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Alleles
- Animals
- Base Sequence
- Bile
- Bilirubin
- Carrier Proteins
- Enzymes
- Homozygote
- Liver
- Liver Diseases