Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of hepatic ABCC transporters by xenobiotics and in disease states

16 Mar 2010

Abstract excerpt

The subfamily of ABCC transporters consists of 13 members in mammals, including the multidrug resistance-associated proteins (MRPs), sulfonylurea receptors (SURs), and the cystic fibrosis transmembrane conductance regulator (CFTR). These proteins play roles in chemical detoxification, disposition, and normal cell physiology. ABCC transporters are expressed differentially in the liver and are regulated at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Pediatric Hepatobiliary Diseases and Treatments
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20233023
DOI: 10.3109/03602531003654915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of hepatic ABCC transporters by xenobiotics and in disease statesPMID 20233023Read ↗

Mammalian ABC Transporters in Health and DiseaseSemantic proximity Read ↗

MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions.Semantic proximity Read ↗

The apical conjugate efflux pump ABCC2 (MRP2).Semantic proximity Read ↗

Xenobiotic transporters: ascribing function from gene knockout and mutation studies.Semantic proximity Read ↗

Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.Semantic proximity Read ↗

Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter ConsortiumSemantic proximity Read ↗

Mammalian multidrug-resistance proteins (MRPs)Semantic proximity Read ↗

Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition.Semantic proximity Read ↗

Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug DevelopmentSemantic proximity Read ↗

Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter ConsortiumSemantic proximity Read ↗

Transporters and drug therapy: implications for drug disposition and disease.Semantic proximity Read ↗

Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.