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Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump #

20 May 2009

Abstract excerpt

UNLABELLED: Bile salt export pump (BSEP; ATP-binding cassette, subfamily B, member 11) mutations in humans result in progressive familial intrahepatic cholestasis type 2, a fatal liver disease with greatly reduced bile flow. However in mice, Bsep knockout leads only to mild cholestasis with substantial bile flow and up-regulated P-glycoprotein genes (multidrug resistance protein 1a [Mdr1a] and Mdr1b). To...

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PMID: 19650158
DOI: 10.1002/hep.23089

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