Article
Genetic aspects of multidrug resistance.
Cancer - 15 Sept 1992
Biedler J L
Abstract excerpt
Mammalian cells exposed to a single cytotoxic natural product drug, such as vincristine or dactinomycin, can develop resistance to the selective agent and cross-resistance to a broad spectrum of structurally and functionally distinct antibiotics and alkaloids. This phenomenon, termed multidrug resistance (MDR), has been widely studied experimentally. The most consistent feature of cells with high-level MDR is...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antibodies, Monoclonal
- Antineoplastic Agents
- Cell Line
- Drug Resistance
- Gene Amplification
- Gene Expression
- Humans
- Membrane Glycoproteins
- Phenotype