Genetic analysis of the multidrug transporter.

doi:10.1146/annurev.ge.29.120195.003135

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Article

Genetic analysis of the multidrug transporter.

Annual review of genetics - 1 Jan 1995

Gottesman M M, Hrycyna C A, Schoenlein P V, Germann U A, Pastan I

Abstract excerpt

The analysis of how human cancers evade chemotherapy has revealed a rich variety of cell-based genetic changes resulting in drug resistance. One of the best studied of these genetic alterations is increased expression of an ATP-dependent plasma membrane transport system, known as P-glycoprotein,...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Animals, Genetically Modified
Drug Resistance, Multiple
Gene Amplification
Gene Expression Regulation
Genetic Markers
Genetic Therapy
Humans
Mutation
Neoplasms
Protein Biosynthesis
Protein Conformation
Protein Processing, Post-Translational

Source

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Identifiers

PMID: 8825488
DOI: 10.1146/annurev.ge.29.120195.003135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8825488-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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