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Article

Genetic analysis of the multidrug transporter.

Annual review of genetics - 1 Jan 1995

Gottesman M M, Hrycyna C A, Schoenlein P V, Germann U A, Pastan I

Abstract excerpt

The analysis of how human cancers evade chemotherapy has revealed a rich variety of cell-based genetic changes resulting in drug resistance. One of the best studied of these genetic alterations is increased expression of an ATP-dependent plasma membrane transport system, known as P-glycoprotein, or the multidrug transporter. This transporter actively effluxes a large number of natural product, hydrophobic,...

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PMID: 8825488
DOI: 10.1146/annurev.ge.29.120195.003135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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