Article
[P glycoprotein and multidrug resistance].
Patologia polska - 1 Jan 1991
Kaczorowski S, Kaczorowska M
Abstract excerpt
Drug resistance has been shown to be associated with the expression of P-glycoprotein (P-gp), the product of mdr-1 gene. One of the suggested mechanisms for the phenomenon called Multidrug Resistance (MDR) is related to the overexpression and amplification of the mdr-1 gene. The product of this gene is called P-gp and it has been considered as a potential marker for drug resistance. Transfection of the mdr-1 gene...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Carrier Proteins
- Drug Resistance
- Gene Expression Regulation
- Humans
- Membrane Glycoproteins
- Phenotype