Article
ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.
Chemico-biological interactions - 24 Apr 1998
Keppler D, Leier I, Jedlitschky G, König J
Abstract excerpt
The membrane proteins mediating the ATP-dependent transport of glutathione S-conjugates and related amphiphilic anions have been identified as the multidrug resistance proteins MRP1 and MRP2. These 190-kDa membrane glycoproteins were cloned in recent years and shown to be unidirectional, ATP-driv...
Topics
- ATP-Binding Cassette Transporters
- Adenosine Triphosphate
- Animals
- Anion Transport Proteins
- Biological Transport, Active
- Carrier Proteins
- Drug Resistance, Multiple
- Glutathione
- Humans
- Inactivation, Metabolic
- Multidrug Resistance-Associated Proteins
- Mutation
- Oxidative Stress
- Recombinant Proteins