Article
Ablation of Go alpha-subunit results in a transformed phenotype and constitutively active phosphatidylcholine-specific phospholipase C.
The Journal of biological chemistry - 11 Jul 1997
Cheng J, Weber J D, Baldassare J J, Raben D M
Abstract excerpt
Modulation of the components involved in mitogenic signaling cascades is critical to the regulation of cell growth. GTP-binding proteins and the stimulation of phosphatidylcholine (PC) hydrolysis have been shown to play major roles in these cascades. One of the enzymes involved in PC hydrolysis,...
Topics
- Animals
- Cell Division
- Cell Transformation, Neoplastic
- Choline Kinase
- Cricetinae
- Cricetulus
- Diglycerides
- Enzyme Activation
- GTP-Binding Protein alpha Subunits, Gi-Go
- GTP-Binding Proteins
- Humans
- Oligonucleotides, Antisense
- Phenotype
- Phosphatidate Phosphatase
- Phosphatidylcholines
- Phosphatidylinositols
- Phospholipase D
- Phospholipases A