Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C.

doi:10.1074/jbc.270.36.21299

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Article

Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C.

The Journal of biological chemistry - 8 Sept 1995

Bjørkøy G, Overvatn A, Diaz-Meco M T, Moscat J, Johansen T

Abstract excerpt

NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC) from Bacillus cereus display a chronic elevation of intracellular diacylglycerol levels and a transformed phenotype. We have used such PC-PLC-transformed cells to evaluate the roles of...

Topics

3T3 Cells
Animals
Cell Transformation, Neoplastic
DNA Replication
Genes, Dominant
Hydrolysis
Mice
Mitogens
Mutation
Oncogene Protein p21(ras)
Phenotype
Phorbol Esters
Phosphatidylcholines
Protein Kinases
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-raf
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 7673165
DOI: 10.1074/jbc.270.36.21299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7673165-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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