Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced phospholipase C stimulation and transformation in NIH-3T3 cells expressing Q209LGq-alpha-subunits.

The Journal of biological chemistry - 15 Sept 1992

De Vivo M, Chen J, Codina J, Iyengar R

Abstract excerpt

NIH-3T3 cells were transfected with cDNA encoding the native alpha-subunit of the G protein Gq(alpha q) or a mutant (Q209L) form of alpha q. Cells expressing Q209L-alpha q showed greatly enhanced basal phospholipase C activity. Stimulation of phospholipase C activity by prostaglandin F2 alpha or fetal calf serum was increased up to 10-fold in Q209L-alpha q-transfected cells. Continuous expression of Q209L-alpha q...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Western
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Molecular Sequence Data

Share to Mutation

Share to Transfection

Source

Identifiers

PMID: 1526966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced phospholipase C stimulation and transformation in NIH-3T3 cells expressing Q209LGq-alpha-subunits.PMID 1526966Read ↗

Mutant alpha subunit of Gz transforms Swiss 3T3 cells.Semantic proximity Read ↗

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.Semantic proximity Read ↗

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.Semantic proximity Read ↗

Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts.Semantic proximity Read ↗

Mitogenic effects of pertussis toxin-sensitive G-protein alpha subunits: the mitogenic action of alpha i2 in NIH 3T3 cells is mimicked by alpha i1, but not alpha i3.Semantic proximity Read ↗

Analysis of the fibroblast transformation potential of GTPase-deficient gip2 oncogenes.Semantic proximity Read ↗

The transforming activity of activated G alpha 12.Semantic proximity Read ↗

Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gs alpha.Semantic proximity Read ↗

Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq.Semantic proximity Read ↗

Inhibition of cell differentiation by G alpha q in the renal epithelial cell line LLC-PK1.Semantic proximity Read ↗

Constitutively active Gq impairs gonadotropin-releasing hormone-induced intracellular signaling and luteinizing hormone secretion in LbetaT2 cells.Semantic proximity Read ↗

Mutations at residues Tyr771 and Tyr783 of phospholipase C-gamma1 have different effects on cell actin-cytoskeleton organization and cell proliferation in CCL-39 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.