Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3.

doi:10.1038/sj.onc.1209132

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Article

Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3.

Oncogene - 9 Feb 2006

Kumar R N, Shore S K, Dhanasekaran N

Abstract excerpt

Galpha(12), the alpha-subunit of G12, which has been referred to as the gep oncogene, stimulates mitogenic pathways in different cell types and readily induces neoplastic transformation of fibroblast cell lines. Recently, we have shown that the oncogenic pathway activated by Galpha(12) involves the receptor tyrosine kinase platelet derived growth factor receptor-alpha (PDGFRalpha) and JAK3. In the present study,...

Topics

3T3 Cells
Animals
Cell Transformation, Neoplastic
Cells, Cultured
Fibroblasts
GTP-Binding Protein alpha Subunits, G12-G13
Humans
Janus Kinase 3
Mice
Mutation
Oncogenes
Phosphatidylinositol 3-Kinases
Phosphorylation
Protein-Tyrosine Kinases
Receptor, Platelet-Derived Growth Factor alpha
STAT3 Transcription Factor
Serine
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 16247467
DOI: 10.1038/sj.onc.1209132

Genes

STAT3
JAK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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