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Article

Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3.

Oncogene - 9 Feb 2006

Kumar R N, Shore S K, Dhanasekaran N

Abstract excerpt

Galpha(12), the alpha-subunit of G12, which has been referred to as the gep oncogene, stimulates mitogenic pathways in different cell types and readily induces neoplastic transformation of fibroblast cell lines. Recently, we have shown that the oncogenic pathway activated by Galpha(12) involves the receptor tyrosine kinase platelet derived growth factor receptor-alpha (PDGFRalpha) and JAK3. In the present study,...

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Source

Identifiers

PMID: 16247467
DOI: 10.1038/sj.onc.1209132

Genes

STAT3
JAK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3.PMID 16247467Read ↗

Transactivation of platelet-derived growth factor receptor alpha by the GTPase-deficient activated mutant of Galpha12.Semantic proximity Read ↗

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JNK-interacting leucine zipper protein is a novel scaffolding protein in the Galpha13 signaling pathway.Semantic proximity Read ↗

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Activation of STAT3 by specific Galpha subunits and multiple Gbetagamma dimers.Semantic proximity Read ↗

G alpha 13-mediated transformation and apoptosis are permissively dependent on basal ERK activity.Semantic proximity Read ↗

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.Semantic proximity Read ↗

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Mutant alpha-subunit of the G protein G12 activates proliferation and inhibits differentiation of 3T3-F442A preadipocytes.Semantic proximity Read ↗

Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts.Semantic proximity Read ↗

Activated mutant of G alpha 13 induces Egr-1, c-fos, and transformation in NIH 3T3 cells.Semantic proximity Read ↗

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