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Article

Requirement for phospholipase C-gamma1 enzymatic activity in growth factor-induced mitogenesis.

Molecular and cellular biology - 1 Jan 1998

Wang Z, Glück S, Zhang L, Moran M F

Abstract excerpt

The cytoplasmic regions of the receptors for epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) bind and activate phospholipase C-gamma1 (PLC-gamma1) and other signaling proteins in response to ligand binding outside the cell. Receptor binding by PLC-gamma1 is a function of its SH2 domains and is required for growth factor-induced cell cycle progression into the S phase. Microinjection into...

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Identifiers

PMID: 9418905
DOI: 10.1128/MCB.18.1.590
PMCID: PMC121526

Genes

CAT
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Requirement for phospholipase C-gamma1 enzymatic activity in growth factor-induced mitogenesis.PMID 9418905Read ↗

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