Requirement for phospholipase C-gamma1 enzymatic activity in growth factor-induced mitogenesis.

doi:10.1128/MCB.18.1.590

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Article

Requirement for phospholipase C-gamma1 enzymatic activity in growth factor-induced mitogenesis.

Molecular and cellular biology - 1 Jan 1998

Wang Z, Glück S, Zhang L, Moran M F

Abstract excerpt

The cytoplasmic regions of the receptors for epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) bind and activate phospholipase C-gamma1 (PLC-gamma1) and other signaling proteins in response to ligand binding outside the cell. Receptor binding by PLC-gamma1 is a function of i...

Topics

3T3 Cells
Animals
Enzyme Activation
Epidermal Growth Factor
Isoenzymes
Mice
Mitogens
Mitosis
Mutation
Phospholipase C gamma
Platelet-Derived Growth Factor
Signal Transduction
Type C Phospholipases

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