Article
Mutant alpha subunit of Gz transforms Swiss 3T3 cells.
Oncogene - 18 May 1995
Wong Y H, Chan J S, Yung L Y, Bourne H R
Abstract excerpt
Many hormones and neurotransmitters induce cell proliferation by regulating signaling pathways controlled by heterotrimeric G proteins. Mutations that activate the alpha subunits of Gs and Gi2 produce the gsp and gip2 oncogenes that are found in certain human endocrine tumors. Similar mutations have conferred on other G alpha subunits the ability to promote neoplastic transformation in cultured mammalian cells....
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