Article
Mutant alpha subunit of Gz transforms Swiss 3T3 cells.
Oncogene - 18 May 1995
Wong Y H, Chan J S, Yung L Y, Bourne H R
Abstract excerpt
Many hormones and neurotransmitters induce cell proliferation by regulating signaling pathways controlled by heterotrimeric G proteins. Mutations that activate the alpha subunits of Gs and Gi2 produce the gsp and gip2 oncogenes that are found in certain human endocrine tumors. Similar mutations h...
Topics
- 3T3 Cells
- Animals
- Cell Adhesion
- Cell Division
- Cell Transformation, Neoplastic
- Cyclic AMP
- DNA
- GTP-Binding Proteins
- Mice
- Mutation
- Tumor Stem Cell Assay