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Article

NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype.

Molecular and cellular biology - 1 Jan 1994

Johansen T, Bjørkøy G, Overvatn A, Diaz-Meco M T, Traavik T, Moscat J

Abstract excerpt

In order to determine whether chronic elevation of intracellular diacylglycerol levels generated by hydrolysis of phosphatidylcholine (PC) by PC-hydrolyzing phospholipase C (PC-PLC) is oncogenic, we generated stable transfectants of NIH 3T3 cells expressing the gene encoding PC-PLC from Bacillus cereus. We found that constitutive expression of this gene (plc) led to transformation of NIH 3T3 cells as evidenced by...

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Identifiers

PMID: 8264633
DOI: 10.1128/mcb.14.1.646-654.1994
PMCID: PMC358414

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