Article
A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1993
Xu N, Bradley L, Ambdukar I, Gutkind J S
Abstract excerpt
The discovery of GTPase-inhibiting mutations in genes for alpha subunits of Gs or G(i2) in certain human endocrine tumors has raised the possibility that heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) might contribute to neoplastic disease. Expression of GTPase-deficie...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Division
- Cell Transformation, Neoplastic
- Cyclic AMP
- Eicosanoids
- Enzyme Activation
- GTP-Binding Proteins
- Inositol Phosphates
- Mice
- Mice, Nude
- Molecular Sequence Data
- Multigene Family
- Mutation
- Neoplasms, Experimental
- Oncogenes