Article
A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1991
Pace A M, Wong Y H, Bourne H R
Abstract excerpt
In a recently discovered class of oncogenes, GTPase-inhibiting mutations constitutively activate alpha subunits of signal-transducing guanine nucleotide-binding proteins (G proteins). Somatic mutations in a subclass of endocrine tumors are found in the arginine-179 codon of the alpha subunit of Gi2 (alpha i2), creating the putative gip2 oncogene. We have tested the ability of gip2 to mediate neoplastic...
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