Article
A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1991
Pace A M, Wong Y H, Bourne H R
Abstract excerpt
In a recently discovered class of oncogenes, GTPase-inhibiting mutations constitutively activate alpha subunits of signal-transducing guanine nucleotide-binding proteins (G proteins). Somatic mutations in a subclass of endocrine tumors are found in the arginine-179 codon of the alpha subunit of G...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Cyclic AMP
- GTP-Binding Proteins
- Genes, ras
- Macromolecular Substances
- Mice
- Mice, Nude
- Mutation
- Neoplasms, Experimental
- Oncogenes
- Rats
- Recombinant Proteins
- Transplantation, Heterologous