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Article

Reduced fertility in mice deficient for the POU protein sperm-1.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 1997

Pearse R V, Drolet D W, Kalla K A, Hooshmand F, Bermingham J R, Rosenfeld M G

Abstract excerpt

Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ systems. Sperm-1 (Sprm-1) is a POU domain factor that is exclusively expressed in the differentiating male germ cell. We show here that the Sprm-1 protein is expressed in the haploid spermatid and that 129/Sv Sprm-1(-/-) mice are subfertile when compared with...

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Identifiers

PMID: 9207130
DOI: 10.1073/pnas.94.14.7555
PMCID: PMC23860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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