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Article

An allele separating skeletal patterning and spermatogonial renewal functions of PLZF.

BMC developmental biology - 25 Mar 2010

Ching Yung-Hao, Wilson Lawriston A, Schimenti John C

Abstract excerpt

BACKGROUND: The promyelocytic leukemia zinc finger gene Plzf (also called Zbtb16, Zfp145 or Green's luxoid) belongs to the POZ/zinc-finger family of transcription factors. It contains a BTB/POZ domain that mediates epigenetic transcriptional repression. PLZF is essential for proper skeleton patterning and male germ cell renewal. Two alleles have been reported that display similar phenotypes: a targeted knock-out,...

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Identifiers

PMID: 20338044
DOI: 10.1186/1471-213X-10-33
PMCID: PMC2859375

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