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Article

Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells.

Developmental biology - 15 Mar 2008

Godmann Maren, Katz Jonathan P, Guillou Florian, Simoni Manuela, Kaestner Klaus H, Behr Rüdiger

Abstract excerpt

Krüppel-like factor 4 (KLF4) is a pleiotropic zinc finger transcription factor that regulates genes being involved in differentiation and cell-cycle control. Knockout studies revealed a critical function for KLF4 in the terminal differentiation of many epithelial cells. In testicular Sertoli cells, Klf4 is strongly inducible by the glycoprotein follicle stimulating hormone (FSH). Because KLF4 is essential for...

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Identifiers

PMID: 18243172
DOI: 10.1016/j.ydbio.2007.12.018
PMCID: PMC2292099

Genes

KLF4

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