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Article

Null mutation of the transcription factor inhibitor of DNA binding 3 (ID3) in male mice adversely impacts on fertility and reproductive outcome.

Journal of andrology - 1 Jan 2000

Carroll Michelle, Robaire Bernard

Abstract excerpt

Inhibitor of DNA binding 3 (ID3) protein binds to and inhibits the function of basic helix-loop-helix transcription factors. The expression of ID3 protein in postproliferative Sertoli cells in the testis, as well as its unique, highly region-specific expression profile along the adult epididymis, implies novel functional roles for this regulator of transcription. The purpose of this study was to determine...

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PMID: 22016354
DOI: 10.2164/jandrol.111.014522

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